Overview
SCIENTIFIC SCORE
Possibly Effective
Based on 14 Researches
7.9
USERS' SCORE
Good
Based on 26 Reviews
8.4
Supplement Facts
Serving Size: 1 Nugget
Amount Per Serving
%DV
Vitamin B12 (as methylcobalamin)
1000 mcg
41,667%
Top Medical Research Studies
8
We examined a case involving a 56-year-old male who suffered from severe vitamin B12 deficiency. This deficiency led to dangerously high homocysteine levels, which are associated with blood clot formation. Despite effective treatment with B12, this case illustrates that vitamin deficiency can lead to significant health issues, including thrombosis and embolism.
The patient’s condition improved with B12 injections, but the interplay between low vitamin levels and clotting risks was evident. It’s clear that while vitamin B12 treatment can help, avoiding complications like blood clots remains crucial.
The patient’s condition improved with B12 injections, but the interplay between low vitamin levels and clotting risks was evident. It’s clear that while vitamin B12 treatment can help, avoiding complications like blood clots remains crucial.
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8
We explored the relationship between nitrous oxide abuse and cerebral venous thrombosis in a 19-year-old female patient. After using nitrous oxide, her vitamin B12 levels dropped significantly, leading to increased homocysteine, a marker associated with clotting issues.
Following vitamin B12 supplementation, her levels normalized, indicating a potential connection between deficiency and clot development. This case suggests that hyperhomocysteinemia, triggered by low B12, may induce cerebral venous thrombosis, emphasizing the need for awareness of vitamin deficiencies related to nitrous oxide use.
Following vitamin B12 supplementation, her levels normalized, indicating a potential connection between deficiency and clot development. This case suggests that hyperhomocysteinemia, triggered by low B12, may induce cerebral venous thrombosis, emphasizing the need for awareness of vitamin deficiencies related to nitrous oxide use.
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8
We explored a compelling case of pernicious anemia that led to a rare presentation of disseminated intravascular coagulation (DIC). The patient, a 63-year-old woman, faced severe anemia and a significant vitamin B12 deficiency.
After diagnosis, she received daily vitamin B12 injections which significantly improved her blood counts and overall health.
This case highlights the importance of early detection and treatment of vitamin B12 deficiency in preventing serious complications like DIC.
After diagnosis, she received daily vitamin B12 injections which significantly improved her blood counts and overall health.
This case highlights the importance of early detection and treatment of vitamin B12 deficiency in preventing serious complications like DIC.
Read More
Most Useful Reviews
9
Quick absorption
5 people found this helpful
A great product! I highly recommend it! The tablets are quickly absorbed, and within a week of use, my blood test indicated a significant improvement! They are small, chewable, and quite tasty. My child (6 years old) enjoys taking them without any fuss.
Read More
10
Working remedy
2 people found this helpful
The level of B12 in my blood has improved remarkably, so I consider this drug effective! This is not my first purchase, and it's always delivered good results.
Read More
10
Significant blood improvement
1 people found this helpful
It works! I've taken it for three months, and my blood levels have increased from 250 to 1100! My doctor mentioned that's a bit too high, so I suggest taking it for a month, pausing for two weeks, and checking the levels.
Read More
Medical Researches
SCIENTIFIC SCORE
Possibly Effective
Based on 14 Researches
7.9
- All Researches
9
This case report examined a 14-year-old girl who experienced cerebral venous thrombosis alongside high homocysteine levels due to a unique genetic mutation at the MTHFR locus.
After beginning treatment with anticoagulants and supplements, including vitamins B12, folate, and B6, we observed significant improvements. Within a month, her headaches vanished, her intracranial pressure dropped, and there was notable shrinkage of the blood clot.
Overall, this implies that proper treatment, including B12, may positively influence recovery in similar cases.
After beginning treatment with anticoagulants and supplements, including vitamins B12, folate, and B6, we observed significant improvements. Within a month, her headaches vanished, her intracranial pressure dropped, and there was notable shrinkage of the blood clot.
Overall, this implies that proper treatment, including B12, may positively influence recovery in similar cases.
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9
We explored a unique case involving a 49-year-old woman who experienced postprandial hypoglycemia following Roux-en-Y gastric bypass surgery. While hypoglycemia is uncommon, her medical history of mesenteric thrombosis and prior anticoagulation treatment contributed to her condition.
We observed that intravenous iron and intramuscular vitamin B12 supplementation effectively addressed her anemia, leading to improved hemoglobin levels. This improvement allowed her to safely resume oral anticoagulation to lower her risk of further thrombotic events.
We observed that intravenous iron and intramuscular vitamin B12 supplementation effectively addressed her anemia, leading to improved hemoglobin levels. This improvement allowed her to safely resume oral anticoagulation to lower her risk of further thrombotic events.
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9
We explored how elevated homocysteine levels, termed hyperhomocysteinemia (HHcy), impact patients with acute brain injuries in neurocritical care. Our systematic review of 33 studies revealed that HHcy is an independent risk factor for various brain injuries and a marker of poor prognosis.
Importantly, we noticed that B vitamins, particularly B12, along with folic acid and B6, play a potential role in mitigating the risk of thrombosis and other complications in these patients. However, the direct effectiveness of B12 treatment on blood clotting in the context of HHcy remains an area for further investigation.
Importantly, we noticed that B vitamins, particularly B12, along with folic acid and B6, play a potential role in mitigating the risk of thrombosis and other complications in these patients. However, the direct effectiveness of B12 treatment on blood clotting in the context of HHcy remains an area for further investigation.
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9
We encountered a compelling case that sheds light on the relationship between vitamin B-12 deficiency and a condition known as pseudo-thrombotic microangiopathic anemia. This condition often mimics more severe blood disorders requiring aggressive treatments. However, during this case, we observed that addressing the deficiency with vitamin B-12 injections led to a significant improvement.
Our patient, a 51-year-old man, originally presented with symptoms like weakness and difficulty breathing, which raised alarms for potential blood issues. Upon extensive examination, he was found to have severe microangiopathic anemia with initial concerns pointing towards serious conditions like thrombotic thrombocytopenic purpura (TTP). Thankfully, after treatment with vitamin B-12 to combat the deficiency caused by pernicious anemia, the patient saw a marked recovery in both his symptoms and blood parameters.
This case highlights the importance of recognizing vitamin deficiencies as a potential cause of blood disorders. It demonstrates that what may appear to be serious hematological issues can sometimes be addressed with simple vitamin supplementation, likely saving patients from unnecessary invasive treatments.
Our patient, a 51-year-old man, originally presented with symptoms like weakness and difficulty breathing, which raised alarms for potential blood issues. Upon extensive examination, he was found to have severe microangiopathic anemia with initial concerns pointing towards serious conditions like thrombotic thrombocytopenic purpura (TTP). Thankfully, after treatment with vitamin B-12 to combat the deficiency caused by pernicious anemia, the patient saw a marked recovery in both his symptoms and blood parameters.
This case highlights the importance of recognizing vitamin deficiencies as a potential cause of blood disorders. It demonstrates that what may appear to be serious hematological issues can sometimes be addressed with simple vitamin supplementation, likely saving patients from unnecessary invasive treatments.
Read More
8
We examined a case involving Biermer's disease, where a 56-year-old man experienced neurological and cardiovascular complications. Despite the serious symptoms of melena, memory issues, and swelling in the leg, he was diagnosed with deep vein thrombosis and severe vitamin B12 deficiency.
After starting treatment with vitamin B12 and anticoagulants, we observed significant clinical improvement. This suggests that B12 supplementation can markedly enhance outcomes for patients with pernicious anemia and related complications.
After starting treatment with vitamin B12 and anticoagulants, we observed significant clinical improvement. This suggests that B12 supplementation can markedly enhance outcomes for patients with pernicious anemia and related complications.
Read More
User Reviews
USERS' SCORE
Good
Based on 26 Reviews
8.4
- All Reviews
- Positive Reviews
- Negative Reviews
9
Quick absorption
5 people found this helpful
A great product! I highly recommend it! The tablets are quickly absorbed, and within a week of use, my blood test indicated a significant improvement! They are small, chewable, and quite tasty. My child (6 years old) enjoys taking them without any fuss.
Read More
10
Working remedy
2 people found this helpful
The level of B12 in my blood has improved remarkably, so I consider this drug effective! This is not my first purchase, and it's always delivered good results.
Read More
10
Significant blood improvement
1 people found this helpful
It works! I've taken it for three months, and my blood levels have increased from 250 to 1100! My doctor mentioned that's a bit too high, so I suggest taking it for a month, pausing for two weeks, and checking the levels.
Read More
9
B12 levels normalised
1 people found this helpful
I was diagnosed with a low B12 level in the blood. After taking this product for six months, my subsequent test showed that my vitamin levels had returned to normal. I would highly recommend it!
Read More
9
Visible results
1 people found this helpful
Good quality! I really liked this B12! I was worried it might arrive broken due to the glass packaging, but it came intact! This sublingual vitamin B12 has a higher dosage than the daily recommendation, and it has a pleasant taste. My blood tests showed a visible improvement. I highly recommend it!
Read More
Frequently Asked Questions
9
Quick absorption
5 people found this helpful
A great product! I highly recommend it! The tablets are quickly absorbed, and within a week of use, my blood test indicated a significant improvement! They are small, chewable, and quite tasty. My child (6 years old) enjoys taking them without any fuss.
7.5
Hemoglobin increase
4 people found this helpful
I found this product beneficial! After two weeks of drinking it, my hemoglobin increased from 111 to 126, which for me is remarkable! It was prescribed by my gastroenterologist due to absorption issues. My blood levels improved significantly. The dosage is good, with excess stored in the body for later use. Very helpful!
10
Significant blood improvement
1 people found this helpful
It works! I've taken it for three months, and my blood levels have increased from 250 to 1100! My doctor mentioned that's a bit too high, so I suggest taking it for a month, pausing for two weeks, and checking the levels.
9
B12 levels normalised
1 people found this helpful
I was diagnosed with a low B12 level in the blood. After taking this product for six months, my subsequent test showed that my vitamin levels had returned to normal. I would highly recommend it!
9
Proven effectiveness
2 people found this helpful
I supplement weekly with methylcobalamin for a confirmed vitamin B12 deficiency. My blood tests confirm this product's effectiveness. Additionally, the price on iHerb is significantly cheaper than in France, even with shipping costs, for a larger quantity of this brand!
9
Key supplement for health
1 people found this helpful
Highly recommended for vegans and vegetarians! I've been taking this for a few months and feel fantastic; my blood tests are better than ever. I use other supplements too, but I believe this one is crucial.
9
Visible results
1 people found this helpful
Good quality! I really liked this B12! I was worried it might arrive broken due to the glass packaging, but it came intact! This sublingual vitamin B12 has a higher dosage than the daily recommendation, and it has a pleasant taste. My blood tests showed a visible improvement. I highly recommend it!
9
Immediate effectiveness
Be cautious, as this has a very high concentration of vitamin B12. The level in my blood rose instantly; it's very effective.
7
We observed that a study looked into how vitamin B12, alongside folic acid and vitamin D3, can influence homocysteine levels in Parkinson's disease patients on levodopa treatment. High homocysteine levels are linked to an increased risk of blood clots and cardiovascular issues.
Over six months, participants taking the supplement showed a significant reduction in homocysteine levels. This points towards a potential link between vitamin B12 intake and better blood health, ultimately leading to improved quality of life for those with Parkinson's.
Over six months, participants taking the supplement showed a significant reduction in homocysteine levels. This points towards a potential link between vitamin B12 intake and better blood health, ultimately leading to improved quality of life for those with Parkinson's.
8
We examined a case involving Biermer's disease, where a 56-year-old man experienced neurological and cardiovascular complications. Despite the serious symptoms of melena, memory issues, and swelling in the leg, he was diagnosed with deep vein thrombosis and severe vitamin B12 deficiency.
After starting treatment with vitamin B12 and anticoagulants, we observed significant clinical improvement. This suggests that B12 supplementation can markedly enhance outcomes for patients with pernicious anemia and related complications.
After starting treatment with vitamin B12 and anticoagulants, we observed significant clinical improvement. This suggests that B12 supplementation can markedly enhance outcomes for patients with pernicious anemia and related complications.
8
We explored the relationship between nitrous oxide abuse and cerebral venous thrombosis in a 19-year-old female patient. After using nitrous oxide, her vitamin B12 levels dropped significantly, leading to increased homocysteine, a marker associated with clotting issues.
Following vitamin B12 supplementation, her levels normalized, indicating a potential connection between deficiency and clot development. This case suggests that hyperhomocysteinemia, triggered by low B12, may induce cerebral venous thrombosis, emphasizing the need for awareness of vitamin deficiencies related to nitrous oxide use.
Following vitamin B12 supplementation, her levels normalized, indicating a potential connection between deficiency and clot development. This case suggests that hyperhomocysteinemia, triggered by low B12, may induce cerebral venous thrombosis, emphasizing the need for awareness of vitamin deficiencies related to nitrous oxide use.
7
We explored the connection between prolonged nitrous oxide use and its effects on blood clotting, particularly in young adults. This was highlighted through a case study of a 20-year-old male who experienced serious complications, including extensive leg thrombosis and pulmonary embolism linked to his chronic use of nitrous oxide.
The study sheds light on the implications of functional vitamin B12 dysfunction resulting from nitrous oxide misuse. We observed that in this particular case, the treatment included not just anticoagulants but also vitamin B12 supplementation. This highlights the multifaceted approach needed when dealing with such severe complications—an approach that emphasizes the potential importance of vitamin B12 but is combined with other treatments.
While vitamin B12 plays a role in managing blood clotting issues, we need to recognize that its effectiveness may vary based on individual circumstances and the presence of other therapies. This case serves as a significant reminder of the dangers of recreational nitrous oxide use and the crucial nature of timely medical intervention to prevent adverse outcomes.
The study sheds light on the implications of functional vitamin B12 dysfunction resulting from nitrous oxide misuse. We observed that in this particular case, the treatment included not just anticoagulants but also vitamin B12 supplementation. This highlights the multifaceted approach needed when dealing with such severe complications—an approach that emphasizes the potential importance of vitamin B12 but is combined with other treatments.
While vitamin B12 plays a role in managing blood clotting issues, we need to recognize that its effectiveness may vary based on individual circumstances and the presence of other therapies. This case serves as a significant reminder of the dangers of recreational nitrous oxide use and the crucial nature of timely medical intervention to prevent adverse outcomes.
References
- Bizouard T, Caplette C, Duval D, Savary D, Douillet D. Right iliac deep vein thrombosis and pulmonary embolism associated with recreational nitrous oxide: a case report. Int J Emerg Med. 2024;17:169. doi:10.1186/s12245-024-00689-z
- Turcu-Stiolica A, Naidin MS, Halmagean S, Ionescu AM, Pirici I. The Impact of the Dietary Intake of Vitamin B12, Folic Acid, and Vitamin D3 on Homocysteine Levels and the Health-Related Quality of Life of Levodopa-Treated Patients with Parkinson's Disease-A Pilot Study in Romania. Diagnostics (Basel). 2024;14. doi:10.3390/diagnostics14151609
- Baby N, George M, Rajasekharan A, Ajith S, Zabeer M, et al. Cerebral Venous Sinus Thrombosis Secondary to Vitamin B12 Deficiency - A Case Series with Emphasis on Food Fortification. Ann Afr Med. 2024;23:496. doi:10.4103/aam.aam_138_23
- Haddad F, Boukhal Z, El Rhaoussi FZ, Tahiri M, Hliwa W, et al. Neurological and Cardiovascular Complications Revealing Biermer's Disease: A Case Report. Cureus. 2024;16:e58601. doi:10.7759/cureus.58601
- Khaliq L, Kabir KF, Pyai K, Hadid T, Collins-Hamel B. A Simple Vitamin Deficiency With Life-Threatening Complications: A Case of B12 Deficiency and Hyperhomocysteinemia-Induced Thrombosis. Cureus. 2023;15:e42908. doi:10.7759/cureus.42908
- Banjongjit A, Sutamnartpong P, Mahanupap P, Phanachet P, Thanakitcharu S. Nitrous Oxide-Induced Cerebral Venous Thrombosis: A Case Report, Potential Mechanisms, and Literature Review. Cureus. 2023;15:e41428. doi:10.7759/cureus.41428
- Zhang M, Shi B, Zhao M. Cerebral venous thrombosis with hyperhomocysteinemia due to loss of heterozygosity at methylenetetrahydrofolate reductase (MTHFR) locus: a case report. BMC Neurol. 2023;23:154. doi:10.1186/s12883-023-03200-y
- Lin SS, Fan IW, Chen CY, Su YJ. A nitrous oxide abuser presenting with cerebral venous thrombosis: A case report. Med Int (Lond). 2022;2:20. doi:10.3892/mi.2022.45
- Coelho T, Freitas A, Carmona Alexandrino H, Pinto S. Roux-en-Y Gastric Bypass Surgery Leading to Postprandial Hypoglycemia: A Case Report. Cureus. 2022;14:e32265. doi:10.7759/cureus.32265
- Mochizuki T, Ryu B, Kushi K, Shima S, Sato S, et al. Cerebral venous thrombosis associated with hyperhomocysteinemia and iron-deficiency anemia induced by autoimmune gastritis: A case report and literature review. Neuroradiol J. 2023;36:491. doi:10.1177/19714009221147224
- Aboona MB, Rapaich L, Etman A, Thomas SW. A Rare Presentation of Pernicious Anemia Manifesting as Disseminated Intravascular Coagulation. J Med Cases. 2022;13:557. doi:10.14740/jmc4020
- Lauretta MP, Melotti RM, Sangermano C, George AM, Badenes R, et al. Homocysteine Plasmatic Concentration in Brain-Injured Neurocritical Care Patients: Systematic Review of Clinical Evidence. J Clin Med. 2022;11. doi:10.3390/jcm11020394
- Mohamed Yile MEH, Berteau E, Ramdani N, Mouyen T, Ferrier N. Uncommon Thromboembolic Events in Young Adults: A Rare Cause Uncovered. Cureus. 2025;17:e76962. doi:10.7759/cureus.76962
- Landry I, Chowdhury T, Hussein S, Thomas L. Life-Threatening Microangiopathy or Vitamin Deficiency: A Case Report of the Clinical Manifestations of Pseudo-Thrombotic Microangiopathic Anemia. Cureus. 2021;13:e20228. doi:10.7759/cureus.20228
